Immunology and Serology questions for the SLLE lab exam.
Immunology / Serology in the SLLE covers the components of the immune system, hypersensitivity, autoimmunity and the serological techniques used to diagnose infectious and immune-mediated disease. Candidates should understand test principles and interpret the infection and autoimmune markers that are commonly requested in clinical laboratories.
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272
immunology and serology practice questions
- 15%
- of the exam
- 8
- subtopics
- Oct 2026
- updated
Inside this topic.
The subtopics our immunology and serology questions cover.
- Antibodies
- Virology
- Methodology
- Bacteriology
- Autoimmunity
- Hypersensitivity
- Immunoglobulins
- Serology
Key facts to remember.
High-yield immunology and serology points to revise before the exam.
- 1
Type I hypersensitivity is IgE-mediated with mast cell degranulation, whereas type IV is delayed and T-cell mediated, as in the tuberculin skin test.
- 2
Rheumatoid factor is an antibody, usually IgM, directed against the Fc portion of IgG; anti-CCP antibodies are more specific for rheumatoid arthritis.
- 3
In a sandwich ELISA the analyte is captured between two antibodies, so the color produced is directly proportional to analyte concentration.
- 4
Fourth-generation HIV screening assays detect both HIV-1/2 antibodies and p24 antigen, shortening the window period compared with antibody-only tests.
- 5
C-reactive protein is an acute-phase protein made by the liver that rises within hours of infection or inflammation.
Sample questions with answers.
10 practice questions for the SLLE Laboratory Technologist & Technician Licensing Exam - Saudi Arabia (Immunology and Serology). Pick an answer to see if you're right, with a full explanation.
Question 1
A screening test for syphilis returns reactive, but the patient has autoimmune disease and no clinical signs. Which statement about the test is MOST accurate?
Question 2
During complement activation, C3 is cleaved into C3a and C3b by which enzyme complex?
Question 3
An antibody reacts with antigens from different animal species. What type of antibody is this?
Question 4
Avidity describes:
Question 5
C3 is cleaved by which enzyme complex during complement activation?
Question 6
A patient with suspected myasthenia gravis should be tested for antibodies against:
Question 7
Which immunoglobulin class has four subclasses?
Question 8
Which HLA antigen is MOST strongly associated with Behçet’s disease?
Question 9
A woman presents with joint pain and deformity upon standing. Which laboratory test is MOST appropriate?
Question 10
A vaccinated individual against hepatitis B will show:
Other topics in this exam.
Immunology and Serology in other exams
Questions, answered
For each type, learn the mechanism and one or two classic examples: type I (IgE, such as anaphylaxis and hay fever), type II (antibody against cell-bound antigen, such as hemolytic transfusion reactions), type III (immune complexes, such as serum sickness) and type IV (T cells, such as contact dermatitis). Questions usually describe a scenario and ask for the type. A one-page summary table works well.
Brucella antibodies are commonly screened with the Rose Bengal plate test and quantified with the standard tube agglutination test to give a titer. Brucella ELISA for IgM and IgG can help distinguish recent from longer-standing infection. Blood culture remains the definitive diagnosis, and suspected Brucella cultures must be handled with appropriate biosafety precautions.
Ready to practise immunology and serology?
All 272 immunology and serology questions, with explanations and a readiness score for this topic.